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KMID : 0923620130130060227
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Immune Network
2013 Volume.13 No. 6 p.227 ~ p.234
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Regulation of Intestinal Homeostasis by Innate Immune Cells
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Kayama Hisako
Nishimura Junichi
Takeda Kiyoshi
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Abstract
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The intestinal immune system has an ability to distinguish be-tween the microbiota and pathogenic bacteria, and then acti-vate pro-inflammatory pathways against pathogens for host defense while remaining unresponsive to the microbiota and dietary antigens. In the intestine, abnormal activation of in-nate immunity causes development of several inflammatory disorders such as inflammatory bowel diseases (IBD). Thus, activity of innate immunity is finely regulated in the intestine. To date, multiple innate immune cells have been shown to maintain gut homeostasis by preventing inadequate adaptive immune responses in the murine intestine. Additionally, sev-eral innate immune subsets, which promote Th1 and Th17 re-sponses and are implicated in the pathogenesis of IBD, have recently been identified in the human intestinal mucosa. The demonstration of both murine and human intestinal innate immune subsets contributing to regulation of adaptive im-munity emphasizes the conserved innate immune functions across species and might promote development of the in-testinal innate immunity-based clinical therapy.
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KEYWORD
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Innate immunity, IBD, Intestinal homeostasis
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